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SAMANTHA KARLE MD
NPI 1831891639
Internal Medicine in Boston, MA

Active since March 17, 2023PECOS Enrolled

NPPES record last updated: July 8, 2026. Verified against the NPPES registry weekly; last sync: November 01, 2026.

Record update history: Jul 8, 2026, Mar 17, 2023 (2 updates tracked since 2023).

About Samantha Karle Md NPPES

Official registry information on file with the National Plan and Provider Enumeration System.

SAMANTHA KARLE MD (NPI 1831891639) is an individual internal medicine provider in Boston, Massachusetts, licensed in Massachusetts (1027044) and active in the NPI registry since March 2023. She is enrolled in Medicare PECOS, is affiliated with Massachusetts General Hospital, and is a graduate of Duke University School Of Medicine (2023).

NPPES Registry Identity

NPI1831891639
Entity TypeIndividualFemale
Primary Taxonomy207R00000X
Provider Legal NameSAMANTHA KARLECredential: MD
Location Address55 FRUIT STBoston, MA 02114-2621
Mailing Address55 Fruit StBoston, MA 02114-2696 · (617) 726-2000
Phone(617) 726-2000
Sole ProprietorNo
Medical School CMSDuke University School Of MedicineGraduated 2023
Enumeration DateMarch 17, 2023
Last NPPES UpdateJuly 8, 20262 updates tracked since enumeration
NPPES CertifiedJuly 8, 2026
✔ NPI 1831891639 is a valid, active identifier and passes the ISO check-digit test.

Specialties & Licenses

★ Primary SpecialtyInternal MedicineAllopathic & Osteopathic Physicians
Taxonomy Code207R00000X
License✔ Licensed in MA · 1027044
Definition
A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults and the elderly. Internists are trained in the diagnosis and treatment of cancer, infections and diseases affecting the heart, blood, kidneys, joints and digestive, respiratory and vascular systems. They are also trained in the essentials of primary care internal medicine, which incorporates an understanding of disease prevention, wellness, substance abuse, mental health and effective treatment of common problems of the eyes, ears, skin, nervous system and reproductive organs.
55 FRUIT ST, Boston, MA 02114
Open in Google Maps ↗

Accepted Insurance

The full list of accepted plans is on the Insurance tab. Issuers include Anthem Blue Cross and Blue Shield.Insurance ›

Medicare Participation & PECOS CMS

Medicare enrollment, assignment, and ordering and referring status from the CMS PECOS system.

Medicare Enrollment Status

✔

Enrolled in Medicare (PECOS)

Samantha Karle Md is registered in the CMS Provider Enrollment, Chain and Ownership System (PECOS).

PECOS PAC ID9032577903
PECOS Enrollment IDI20260913000016
Eligible to Order & Refer✔ Part B Labs & Imaging✔ Durable Medical Equipment✔ Home Health Agency✔ Power Mobility DevicesPer the CMS Ordering and Referring file. Eligibility means Medicare pays claims that this provider orders or refers for these categories.

Hospital Affiliations CMS Care Compare

Hospitals where this provider delivers care, identified from recent Medicare claims and place-of-service records.

Massachusetts General Hospital

Acute Care Hospitals · Boston, MA
5/5 CMS rating
OwnershipVoluntary non-profit - Private
CMS Certification Number220071
Location55 Fruit StreetBoston, MA 02114 · Suffolk County
Emergency services Birthing friendly

Physician Visit Costs CMS claims · ZIP area

Typical Medicare office-visit costs in the 02114 ZIP code area, from fee-for-service claims. These are area statistics, not this provider’s prices; actual charges vary by service and coverage.

New Patient
$144.11 typical visit price
range $63.72 – $189.86
Typical copayment $36.02 (range $15.93 – $47.46)
Most-billed visit code 99204
Established Patient
$111.18 typical visit price
range $21.07 – $155.29
Typical copayment $27.79 (range $5.26 – $38.82)
Most-billed visit code 99214
Amounts reflect what Medicare beneficiaries in this ZIP area are typically charged for office visits. Patients with other coverage should check their individual plans.

Other Providers at the Same Location NPPES 20

Providers registered at the same practice address, or within the immediate area, according to the NPPES registry.

STUTI GIRISH SHROFF MD, MBBS
Pathology (Anatomic Pathology)
55 FRUIT ST
BOSTON, MA 02114
Suffolk County (617) 726-2971
NANCY WANG M.D.
Internal Medicine (Hematology & Oncology)
55 FRUIT ST
BOSTON, MA 02114
Suffolk County (017) 724-4000
DR. DUSAN HANIDZIAR M.D., PH.D.
Anesthesiology
55 FRUIT ST, GRAY-BIGELOW 444
BOSTON, MA 02114
Suffolk County (617) 726-3030
JOHN JOSEPH DANKO DO
Physical Medicine & Rehabilitation
55 FRUIT ST
BOSTON, MA 02114
Suffolk County (617) 726-2000
DR. MICHAEL ANDREW LOBRITZ M.D, PH.D.
Internal Medicine (Infectious Disease)
55 FRUIT ST, DIVISION OF INFECTIOUS DISEASE, GRJ-504
BOSTON, MA 02114
Suffolk County (617) 724-9248
MS. KELLY ELISHA TRECARTIN NP
Nurse Practitioner (Acute Care)
55 FRUIT ST, BIGALOW 852 F
BOSTON, MA 02114
Suffolk County (617) 726-7400
JAMIE MARIE ALLEN NP
Nurse Practitioner
55 FRUIT ST
BOSTON, MA 02114
Suffolk County (617) 724-4410
DR. DHAVAL SANJEEV KOLTE M.B.B.S., PH.D.
Internal Medicine (Cardiovascular Disease)
55 FRUIT ST
BOSTON, MA 02114
Suffolk County (617) 643-3238

Frequently Asked Questions NPPES & CMS

Common questions about this NPI record, answered from the official NPPES registry and CMS datasets shown on this page.

What is Samantha Karle's NPI number?

The NPI number for Samantha Karle is 1831891639. It was assigned to this individual provider in the NPPES registry on March 17, 2023.

Where is Samantha Karle located?

Samantha Karle practices at 55 Fruit St, Boston, MA 02114. The listed phone number is (617) 726-2000.

What is Samantha Karle's specialty?

The primary specialty registered for this NPI is Internal Medicine with taxonomy code 207R00000X.

Is Samantha Karle enrolled in Medicare?

Yes. Samantha Karle is registered in the Medicare PECOS enrollment system.

What insurance does Samantha Karle accept?

Health plans from Anthem Blue Cross and Blue Shield list Samantha Karle as in-network in at least one marketplace plan. Coverage varies by plan and year; verify with the insurer or the provider before a visit.

Is Samantha Karle affiliated with any hospitals?

According to CMS data, Samantha Karle is affiliated with Massachusetts General Hospital.

When was this NPI record last updated?

The NPPES record for Samantha Karle was last updated on July 8, 2026. NPI Profile syncs weekly with the NPPES registry data releases published by CMS. This NPI record was last updated 4 months ago. If this record has changed at CMS more recently, you can request an on-demand re-check against the live CMS registry, directly from this page.