DR. KAREN MELINDA ISAACS MD
NPI 1457589533
Family Medicine in Greer, SC

Q: What is Karen Isaacs's NPI number?

The NPI number for Karen Isaacs is 1457589533. It was assigned to this individual provider in the NPPES registry on June 26, 2009.

Q: What is Karen Isaacs's specialty?

The primary specialty registered for this NPI is Family Medicine with taxonomy code 207Q00000X.

Q: When was this NPI record last updated?

The NPPES record for Karen Isaacs was last updated on June 23, 2025. NPI Profile syncs weekly with the NPPES registry data releases published by CMS. This NPI record was last updated 15 months ago. If this record has changed at CMS more recently, you can request an on-demand re-check against the live CMS registry, directly from this page.

Active since June 26, 2009PECOS EnrolledAccepts Medicare Assignment

109 PHYSICIANS DR, GREER, SC 29650(864) 797-9150(864) 797-9155 Get Directions Write a Review

NPPES record last updated: June 23, 2025. Verified against the NPPES registry weekly; last sync: October 18, 2026.

Record update history: Jun 23, 2025, May 27, 2021, Mar 4, 2021 (3 updates tracked since 2021).

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About Dr. Karen Melinda Isaacs Md NPPES

Official registry information on file with the National Plan and Provider Enumeration System.

DR. KAREN MELINDA ISAACS MD (NPI 1457589533) is an individual family medicine provider in Greer, South Carolina, licensed in South Carolina (93966) and active in the NPI registry since June 2009. She is enrolled in Medicare PECOS, is affiliated with Watauga Medical Center, and maintains a secondary practice location in Wilmington.

NPPES Registry Identity

NPI1457589533

Entity TypeIndividualFemale

Primary Taxonomy207Q00000X

Provider Legal NameDR. KAREN MELINDA ISAACSCredential: MD

Location Address109 PHYSICIANS DRGreer, SC 29650-2446

Mailing Address300 E Mcbee Ave Fl 4Greenville, SC 29601-2842 · (864) 695-6697

Phone(864) 797-9150

Fax(864) 797-9155

Sole ProprietorNo

Medical School CMSWake Forest University School Of MedicineGraduated 2009

Enumeration DateJune 26, 2009

Last NPPES UpdateJune 23, 20253 updates tracked since enumeration

NPPES CertifiedJune 23, 2025

✔ NPI 1457589533 is a valid, active identifier and passes the ISO check-digit test.

Specialties & Licenses

★ Primary SpecialtyFamily MedicineAllopathic & Osteopathic Physicians

Taxonomy Code207Q00000X

Licenses✔ Licensed in SC · 93966✔ Licensed in NC · 201101212

Definition

Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadth which integrates the biological, clinical, and behavioral sciences. The scope of family medicine is not limited by age, sex, organ system, or disease entity.

109 PHYSICIANS DR, Greer, SC 29650

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Secondary Practice Location 1

Location 12523 Delaney AveWilmington, NC 28403-6003 · Phone (910) 772-9202 ext. 402 · Fax (910) 772-9452

Accepted Insurance

The full list of accepted plans is on the Insurance tab. Issuers include Blue Cross and Blue Shield of NC, BlueCross BlueShield of South Carolina, InStil Health.Insurance ›

Medicare Participation & PECOS CMS

Medicare enrollment, assignment, billing reassignment, and ordering and referring status from CMS.

Medicare Enrollment Status

✔

Enrolled in Medicare and accepts Medicare assignment

Dr. Karen Melinda Isaacs Md is registered in PECOS and agrees to accept the Medicare-approved amount as full payment. Medicare patients are not billed beyond the standard deductible and coinsurance.

PECOS PAC ID345496923

PECOS Enrollment IDI20250428004266

Eligible to Order & Refer✔ Part B Labs & Imaging✔ Durable Medical Equipment✔ Home Health Agency✔ Power Mobility DevicesPer the CMS Ordering and Referring file. Eligibility means Medicare pays claims that this provider orders or refers for these categories.

Medicare Billing Reassignments

Medicare enrollment records show Karen Isaacs reassigns Medicare billing to 4 organizations. Each organization bills Medicare for the services this provider delivers there; the nearest is listed first.

Prisma Health University Medical Group

4.2 mi

Pediatrics

4501 OLD SPARTANBURG RD STE 9
Taylors, SC 29687

Reassigned Medicare billing, South Carolina enrollment
3,281 clinicians in this Medicare group

NPI 1801524392 (864) 292-8868

Appalachian Regional Medical Associates, Inc.

94 mi

Family Medicine

336 DEERFIELD ROAD
Boone, NC 28607

Reassigned Medicare billing, North Carolina enrollment
207 clinicians in this Medicare group

NPI 1669533923 (828) 262-4100

Novant Health Medical Group Coastal Region, LLC

221 mi

Hematology & Oncology

75 EMERSON BAY RD STE 104
Carolina Shores, NC 28467

Reassigned Medicare billing, North Carolina enrollment
710 clinicians in this Medicare group

NPI 1801565684 (910) 667-4283

Novant Health New Hanover Regional Medical Center LLC

251 mi

Thoracic Surgery (Cardiothoracic Vascular Surgery)

1912 TRADD CT
Wilmington, NC 28401

Reassigned Medicare billing, North Carolina enrollment
335 clinicians in this Medicare group

NPI 1326635418 (910) 815-5982

Source: CMS Revalidation Reassignment List, October 2026 release. Reassignment records can lag staffing changes; confirm a current affiliation with the organization.

Areas of Expertise CMS Part B claims 12

Services this provider delivered to Medicare fee-for-service patients, from the CMS Medicare utilization data. Higher counts generally reflect more experience with a service; care delivered outside Medicare is not included.

Insertion of needle into vein for collection of blood sample 36415

This procedure involves inserting a small needle into a vein, typically in your arm, to collect a blood sample. It's a quick and simple process to help diagnose or monitor health conditions. You may feel a small prick, but discomfort is minimal.

179 services165 patients

Established patient office or other outpatient visit with moderate level of decision making, if using time, 30 minutes or more 99214

This is a routine check-up for patients who have previously visited our clinic. It involves a comprehensive review of your health and any ongoing treatments. The consultation lasts between 30-39 minutes, allowing enough time to discuss any concerns.

149 services120 patients

Subsequent hospital care with moderate levelof medical decision making, if using time, at least 35 minutes 99232

Follow-up hospital inpatient care involves daily check-ups while you're admitted in the hospital. Typically, a healthcare provider spends about 25 minutes each day reviewing your condition, adjusting treatment if needed, and answering any questions you might have.

127 services40 patients

Established patient office or other outpatient visit with low level od decision making, if using time, 20 minutes or more 99213

This is a routine visit for patients who have already been seen by the healthcare provider. During this approximately 20-29 minute appointment, your health status will be evaluated and any necessary treatments or tests will be discussed. It's a chance to address any health concerns you may have.

115 services103 patients

Subsequent hospital care with moderate levelof medical decision making, if using time, at least 50 minutes 99233

Follow-up hospital inpatient care per day typically involves a 35-minute check-up by your healthcare provider. This service includes monitoring your health progress, adjusting your treatment plan if needed, and answering any questions you may have about your condition or care.

38 services16 patients

Hospital discharge day management, 30 minutes or less 99238

Hospital discharge day management of 30 minutes or less includes finalizing your treatment, discussing your progress, and planning after-care at home. It ensures you're ready to leave the hospital and continue recovery safely.

30 services29 patients

Administration of influenza virus vaccine G0008

The administration of the influenza virus vaccine, also known as the flu shot, is a simple procedure to protect against the flu. A healthcare provider injects a small dose of the vaccine into your arm. This stimulates your immune system to produce antibodies, which will help your body fight off the flu if exposed.

19 services19 patients

Initial hospital care with moderate level of medical decision making, if using time, at least 75 minutes 99223

Initial hospital inpatient care per day, typically 70 minutes, refers to the daily medical service provided to patients admitted to the hospital. This includes a comprehensive evaluation, diagnosis, treatment plan, and monitoring of your health condition. It ensures your well-being during your hospital stay.

17 services17 patients

Influenza vaccine split virus, preservative free 90662

The Influenza Vaccine Split Virus, preservative-free, is a flu shot to protect against the influenza virus. It is made from parts of inactivated flu viruses and doesn't contain preservatives, reducing potential side effects. It helps your body develop immunity to the flu.

15 services15 patients

Automated urinalysis test 81003

An automated urinalysis test is a routine examination that checks your urine for various substances. It can help identify potential health issues such as kidney problems or diabetes. The test uses a machine to analyze a small urine sample, providing quick and accurate results.

14 services14 patients

New patient office or other outpatient visit with moderate level of medical decision making, if using time, 45 minutes or more 99204

This is a first-time office or outpatient visit lasting between 45-59 minutes. The healthcare provider evaluates your health, discusses your medical history, and may suggest further tests or treatments. It's an opportunity to ask questions and understand your health better.

12 services12 patients

Administration of pneumococcal vaccine G0009

The pneumococcal vaccine helps protect against pneumococcal bacteria, which can cause severe infections like pneumonia and meningitis. The vaccine is given as an injection, typically in the arm. It's recommended for infants, older adults, and those with certain health conditions.

11 services11 patients

Hospital Affiliations CMS Care Compare 4

Hospitals where this provider delivers care, identified from recent Medicare claims and place-of-service records.

Watauga Medical Center

Acute Care Hospitals · Boone, NC

3/5 CMS rating

OwnershipGovernment - Local

CMS Certification Number340051

Location336 Deerfield RoadBoone, NC 28607 · Watauga County

Emergency services Birthing friendly

Prisma Health Greer Memorial Hospital

Acute Care Hospitals · Spartanburg, SC

4/5 CMS rating

OwnershipVoluntary non-profit - Private

CMS Certification Number420033

Location1413 John B White Sr Blvd Suite DSpartanburg, SC 29306 · Spartanburg County

Emergency services Birthing friendly

Prisma Health Greenville Memorial Hospital

Acute Care Hospitals · Greenville, SC

3/5 CMS rating

OwnershipVoluntary non-profit - Private

CMS Certification Number420078

Location701 Grove RoadGreenville, SC 29605 · Greenville County

Birthing friendly

Prisma Health Patewood Hospital

Acute Care Hospitals · Greenville, SC

5/5 CMS rating

OwnershipVoluntary non-profit - Private

CMS Certification Number420102

Location175 Patewood DriveGreenville, SC 29615 · Greenville County

Birthing friendly

Physician Visit Costs CMS claims · ZIP area

Typical Medicare office-visit costs in the 29650 ZIP code area, from fee-for-service claims. These are area statistics, not this provider’s prices; actual charges vary by service and coverage.

New Patient

$83.18 typical visit price

range $53.57 – $163.84

Typical copayment $20.79 (range $13.39 – $40.96)

Most-billed visit code 99203

Established Patient

$95.12 typical visit price

range $16.96 – $133.52

Typical copayment $23.78 (range $4.24 – $33.38)

Most-billed visit code 99214

Amounts reflect what Medicare beneficiaries in this ZIP area are typically charged for office visits. Patients with other coverage should check their individual plans.

Other Providers at the Same Location NPPES 20

Providers registered at the same practice address, or within the immediate area, according to the NPPES registry.

JESSICA NIX COPLIN

Family Medicine