Recently Updated NPI Information — some details in this NPI profile have been updated in the NPI registry within the last 60 days.

DR. JAMES W WILKERSON MD
NPI 1285612820
Family Medicine in Poplar Bluff, MO

Active since January 04, 2006PECOS EnrolledAccepts Medicare Assignment
92.57/100
CMS Quality Rating
225 PHYSICIANS PARK STE 304, POPLAR BLUFF, MO 63901(573) 727-5500(573) 399-2646 Get Directions Write a Review

NPPES record last updated: October 13, 2026. Verified against the NPPES registry weekly; last sync: October 18, 2026.

Record update history: Oct 13, 2026, Sep 22, 2026, Aug 28, 2026 and 4 more (7 updates tracked since 2021).

About Dr. James W Wilkerson Md NPPES

Official registry information on file with the National Plan and Provider Enumeration System.

DR. JAMES W WILKERSON MD (NPI 1285612820) is an individual family medicine provider in Poplar Bluff, Missouri, licensed in Missouri (2000151570) and active in the NPI registry since January 2006. He is enrolled in Medicare PECOS, is affiliated with Missouri Delta Medical Center, and maintains 25 additional practice locations.

NPPES Registry Identity

NPI1285612820
Entity TypeIndividualMale
Primary Taxonomy207Q00000X
Provider Legal NameDR. JAMES W WILKERSONCredential: MD
Location Address225 PHYSICIANS PARK STE 304Poplar Bluff, MO 63901-3930
Mailing Address110 S 2nd StEllington, MO 63638-9400 · (573) 663-2313 · Fax (573) 663-2441
Fax(573) 399-2646
Sole ProprietorNo
Medical School CMSUniversity Of Missouri, Columbia School Of MedicineGraduated 1995
Enumeration DateJanuary 4, 2006
Last NPPES UpdateOctober 13, 20267 updates tracked since enumeration
NPPES CertifiedOctober 13, 2026
✔ NPI 1285612820 is a valid, active identifier and passes the ISO check-digit test.

Specialties & Licenses

★ Primary SpecialtyFamily MedicineAllopathic & Osteopathic Physicians
Taxonomy Code207Q00000X
License✔ Licensed in MO · 2000151570
Definition
Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadth which integrates the biological, clinical, and behavioral sciences. The scope of family medicine is not limited by age, sex, organ system, or disease entity.
225 PHYSICIANS PARK STE 304, Poplar Bluff, MO 63901

Secondary Practice Locations 25

Location 12879 James BlvdPoplar Bluff, MO 63901-3395 · Phone (573) 609-8800 · Fax (573) 776-6124
Location 2289 Broadway StNeelyville, MO 63954-7176 · Phone (573) 804-9494 · Fax (573) 804-9493
Location 3225 Physicians Park Ste 102Poplar Bluff, MO 63901-3918 · Phone (573) 727-5500 ext. 2 · Fax (573) 413-4609
Location 4101 E Batten StreetNaylor, MO 63953 · Phone (573) 804-1779 · Fax (573) 804-1789
Location 5109 LeRoux StDoniphan, MO 63935-1038 · Phone (573) 996-2136 · Fax (573) 996-5216
Location 6225 Physicians Park Ste 200Poplar Bluff, MO 63901-3921 · Phone (573) 727-5500 ext. 5 · Fax (573) 313-3684
Location 7603 E Summit StDoniphan, MO 63935-1142 · Phone (573) 996-3667 ext. 1117 · Fax (573) 413-4487
Location 83001 Warrior Ln Ste APoplar Bluff, MO 63901-8685 · Phone (573) 785-7453 · Fax (573) 785-7429
Location 9405 Main StreetVan Buren, MO 63965 · Phone (573) 323-4253 · Fax (573) 323-0154
Location 1018 Viburnum Center RdViburnum, MO 65566-7802 · Phone (573) 244-5406 · Fax (573) 244-5591
Location 1117959 Main StEminence, MO 65466-6375 · Phone (573) 226-5505 · Fax (573) 226-1256
Location 12220 East Broad StreetNaylor, MO 63953 · Phone (573) 399-2311 · Fax (573) 399-2076
Location 13202 Allen StAnnapolis, MO 63620-8778 · Phone (573) 598-4213 · Fax (573) 598-1101
Location 14225 Physicians Park Ste 104Poplar Bluff, MO 63901-3918 · Phone (573) 413-4065 · Fax (573) 354-5013
Location 15711 Nickey StPoplar Bluff, MO 63901-6544 · Phone (573) 785-7047 ext. 13040 · Fax (573) 413-4192
Location 1661 Highway YEllington, MO 63638-7802 · Phone (573) 663-2525 · Fax (573) 663-7844
Location 17109 Plum St Ste CDoniphan, MO 63935-1225 · Phone (573) 351-0150
Location 18109 Plum St Ste BDoniphan, MO 63935-1225 · Phone (573) 351-0220 · Fax (573) 996-2246
Location 191 Hals Plz Ste APiedmont, MO 63957-1631 · Phone (573) 223-4800 · Fax (573) 223-7911
Location 2011001 US-160Harviell, MO 63945 · Phone (573) 804-9561 · Fax (573) 804-9581
Location 21315 W Mulberry Ste APilot Knob, MO 63663-7883 · Phone (573) 546-0602 · Fax (573) 546-0546
Location 221300 Victory LnPoplar Bluff, MO 63901-3300 · Phone (573) 785-5566 ext. 17097 · Fax (573) 413-4194
Location 233277 US Highway 160 WDoniphan, MO 63935-5710 · Phone (573) 804-9527 · Fax (573) 804-9536
Location 242300 Baugh LnPoplar Bluff, MO 63901-2402 · Phone (573) 785-3037 ext. 16044 · Fax (573) 413-4506
Location 25109 Plum St Ste ADoniphan, MO 63935-1225 · Phone (573) 351-0150 · Fax (573) 996-2245

Accepted Insurance

Medicare Participation & PECOS CMS

Medicare enrollment, assignment, billing reassignment, and ordering and referring status from CMS.

Medicare Enrollment Status

✔

Enrolled in Medicare and accepts Medicare assignment

Dr. James W Wilkerson Md is registered in PECOS and agrees to accept the Medicare-approved amount as full payment. Medicare patients are not billed beyond the standard deductible and coinsurance.

PECOS PAC ID7618887480
PECOS Enrollment IDI20100602000413
Eligible to Order & Refer✔ Part B Labs & Imaging✔ Durable Medical Equipment✔ Home Health Agency✔ Power Mobility DevicesPer the CMS Ordering and Referring file. Eligibility means Medicare pays claims that this provider orders or refers for these categories.

Medicare Billing Reassignments

2

Medicare enrollment records show James Wilkerson reassigns Medicare billing to 2 organizations. Each organization bills Medicare for the services this provider delivers there; the nearest is listed first.

Physiological Laboratory
225 PHYSICIANS PARK STE 104
Poplar Bluff, MO 63901
  • Reassigned Medicare billing, Missouri enrollment
  • 104 clinicians in this Medicare group
Radiology
223 PHYSICIANS PARK
Poplar Bluff, MO 63901
  • Reassigned Medicare billing, Missouri enrollment
  • 595 clinicians in this Medicare group

Source: CMS Revalidation Reassignment List, October 2026 release. Reassignment records can lag staffing changes; confirm a current affiliation with the organization.

Hospital Affiliations CMS Care Compare 3

Hospitals where this provider delivers care, identified from recent Medicare claims and place-of-service records.

Missouri Delta Medical Center

Acute Care Hospitals · Sikeston, MO
2/5 CMS rating
OwnershipVoluntary non-profit - Private
CMS Certification Number260113
Location1008 North Main StSikeston, MO 63801 · Scott County
Emergency services Birthing friendly

Poplar Bluff Regional Medical Center

Acute Care Hospitals · Poplar Bluff, MO
2/5 CMS rating
OwnershipProprietary
CMS Certification Number260119
Location3100 Oak Grove RoadPoplar Bluff, MO 63901 · Butler County
Emergency services Birthing friendly

Saint Francis Medical Center

Acute Care Hospitals · Cape Girardeau, MO
2/5 CMS rating
OwnershipVoluntary non-profit - Private
CMS Certification Number260183
Location211 St Francis DrCape Girardeau, MO 63703 · Cape Girardeau County
Emergency services Birthing friendly

Physician Visit Costs CMS claims · ZIP area

Typical Medicare office-visit costs in the 63901 ZIP code area, from fee-for-service claims. These are area statistics, not this provider’s prices; actual charges vary by service and coverage.

New Patient
$81.64 typical visit price
range $52.28 – $161.24
Typical copayment $20.41 (range $13.07 – $40.31)
Most-billed visit code 99203
Established Patient
$93.24 typical visit price
range $16.30 – $131.05
Typical copayment $23.31 (range $4.07 – $32.76)
Most-billed visit code 99214
Amounts reflect what Medicare beneficiaries in this ZIP area are typically charged for office visits. Patients with other coverage should check their individual plans.

Medicare Quality Performance CMS QPP · MIPS

Performance in the CMS Quality Payment Program: the MIPS final score across four weighted categories, and the individual quality measures reported to Medicare.

92.57/100
MIPS Final ScoreMerit-based Incentive Payment System · CMS Quality Payment Program
Scored through an Alternative Payment Model
Quality85.03
Promoting Interoperability88
Improvement Activities40

Referred Medical Equipment & Supplies CMS DME claims 19

Durable medical equipment, devices and supplies this provider ordered from DME suppliers for patients, from Medicare fee-for-service claims.

Blood glucose test or reagent strips for home blood glucose monitor, per 50 strips A4253
DME-Other DME · category DE017N
13 suppliers113 claims257 services$6.31 avg. paid by Medicare
Lancets, per box of 100 A4259
DME-Medical/Surgical Supplies · category DA000N
8 suppliers43 claims47 services$1.08 avg. paid by Medicare
Ostomy pouch, drainable, with barrier attached, with filter (1 piece), each A4424
DME-Orthotic Devices · category DF010N
1 supplier11 claims220 services$4.18 avg. paid by Medicare
Full face mask used with positive airway pressure device, each A7030
DME-Other DME · category DE001N
6 suppliers11 claims11 services$119.87 avg. paid by Medicare
Cushion for use on nasal mask interface, replacement only, each A7032
DME-Other DME · category DE001N
5 suppliers21 claims117 services$24.57 avg. paid by Medicare
Nasal interface (mask or cannula type) used with positive airway pressure device, with or without head strap A7034
DME-Other DME · category DE001N
6 suppliers25 claims25 services$65.81 avg. paid by Medicare
Dollar amounts are the average Medicare paid the supplier per service. They are not the cost to the patient.

Other Providers at the Same Location NPPES 20

Providers registered at the same practice address, or within the immediate area, according to the NPPES registry.

Pediatrics
225 PHYSICIANS PARK STE 304
POPLAR BLUFF, MO 63901
Nurse Practitioner (Family)
225 PHYSICIANS PARK STE 304
POPLAR BLUFF, MO 63901
Social Worker (Clinical)
225 PHYSICIANS PARK STE 304
POPLAR BLUFF, MO 63901
Nurse Practitioner (Family)
225 PHYSICIANS PARK STE 304
POPLAR BLUFF, MO 63901
Nurse Practitioner (Family)
225 PHYSICIANS PARK STE 304
POPLAR BLUFF, MO 63901
Counselor (Professional)
225 PHYSICIANS PARK STE 304
POPLAR BLUFF, MO 63901
Psychologist (Clinical)
225 PHYSICIANS PARK STE 304
POPLAR BLUFF, MO 63901
Clinic/Center (Federally Qualified Health Center (FQHC))
225 PHYSICIANS PARK STE 304
POPLAR BLUFF, MO 63901

Frequently Asked Questions NPPES & CMS

Common questions about this NPI record, answered from the official NPPES registry and CMS datasets shown on this page.

What is James Wilkerson's NPI number?

The NPI number for James Wilkerson is 1285612820. It was assigned to this individual provider in the NPPES registry on January 4, 2006.

Where is James Wilkerson located?

James Wilkerson practices at 225 Physicians Park Ste 304, Poplar Bluff, MO 63901. The listed phone number is (573) 727-5500.

What is James Wilkerson's specialty?

The primary specialty registered for this NPI is Family Medicine with taxonomy code 207Q00000X.

Is James Wilkerson enrolled in Medicare?

Yes. James Wilkerson is registered in the Medicare PECOS system and accepts Medicare assignment, which means accepting the Medicare-approved amount as payment in full for covered services.

Which organizations bill Medicare for James Wilkerson's services?

According to the CMS Revalidation Reassignment List (October 2026 release), James Wilkerson reassigns Medicare benefits to 2 organizations: Big Springs Medical Association (Poplar Bluff, MO) and Saint Francis Medical Center (Poplar Bluff, MO). Each reassignment is filed with Medicare on form CMS-855R, signed by both the clinician and the organization, and lets the organization bill Medicare and receive payment for James Wilkerson's services. Reassignment records can lag staffing changes; confirm current arrangements with the organization.

What insurance does James Wilkerson accept?

Health plans from Ambetter Health, Ambetter Health of Delaware, Ambetter from Arkansas Health & Wellness, Ambetter from Sunflower Health Plan and Ambetter of Oklahoma and 3 other insurers list James Wilkerson as in-network in at least one marketplace plan. Coverage varies by plan and year; verify with the insurer or the provider before a visit.

Is James Wilkerson affiliated with any hospitals?

According to CMS data, James Wilkerson is affiliated with Missouri Delta Medical Center, Poplar Bluff Regional Medical Center and Saint Francis Medical Center.

When was this NPI record last updated?

The NPPES record for James Wilkerson was last updated on October 13, 2026. NPI Profile syncs weekly with the NPPES registry data releases published by CMS. This NPI record was last updated 10 days ago. If this record has changed at CMS more recently, you can request an on-demand re-check against the live CMS registry, directly from this page.